A20-Binding Inhibitor of Nuclear Factor-κB Targets β-Arrestin2 to Attenuate Opioid Tolerance
Better medicines are needed to relieve pain
New experimental painkiller is like stronger morphine without the addiction: The drug, called AT-121, targets the same opioid receptors in the brain but also latches on to nociception receptors, that block the
Spurred by opioid epidemic, new pain drugs may lower the risk of overdose and addiction, Science
Efficacy and safety of Opioids - Consumer Reports
A nontoxic pain killer designed by modeling of pathological receptor conformations
Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids - ScienceDirect
Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
In Search Of An Opioid That Offers Help Without The Risks : Shots - Health News : NPR
Opioid analgesics pass the acid test - The Lancet
Intrathecal Pain Pump - A Review